Rab GTPase prenylation hierarchy and its potential role in choroideremia disease.
Protein prenylation is a widespread post-translational modification Tanks/Jerseys in eukaryotes that plays a crucial role in membrane targeting and signal transduction.RabGTPases is the largest group of post-translationally C-terminally geranylgeranylated.All Rabs are processed by Rab geranylgeranyl-transferase and Rab escort protein (REP).Human ge